| 1921 | ||
|---|---|---|
| SECTIONALS | ||
| SITE | WINNER | CLASS |
| Anderson | Anderson | |
| Attica | Pine Village | |
| Auburn | Angola | |
| Bedford | Bedford | |
| Bloomington | Bloomington | |
| Bluffton | Monroe | |
| Columbus | Columbus | |
| Crawfordsville | Crawfordsville | |
| Fort Wayne | Kendallville | |
| Franklin | Franklin | |
| Gary | Whiting | |
| Greencastle | Russellville | |
| Huntington | Huntington | |
| Indianapolis | Indianapolis Tech | |
| Kokomo | Arcadia | |
| Lafayette Jeff | Lafayette Jeff | |
| Lebanon | Frankfort | |
| Logansport | Walton | |
| Marion | Marion | |
| Martinsville | Martinsville | |
| New Castle | Muncie Central | |
| Owensville | Evansville | |
| Richmond | Richmond | |
| Rochester | Rochester | |
| Rushville | Sandusky | |
| Scottsburg | Scottsburg | |
| South Bend | South Bend | |
| Sullivan | Sullivan | |
| Terre Haute | Terre Haute Garfield | |
| Vincennes Lincoln | Vincennes Lincoln | |
| Warsaw | Syracuse | |
| Winchester | Ridgeville | |
| REGIONALS | ||
| SITE | WINNER | CLASS |
| Indiana University | Bloomington | |
| Indiana University | Franklin | |
| Indiana University | Martinsville | |
| Indiana University | Muncie Central | |
| Indiana University | Ridgeville | |
| Indiana University | Russellville | |
| Indiana University | Sandusky | |
| Indiana University | Vincennes Lincoln | |
| Purdue University | Anderson | |
| Purdue University | Frankfort | |
| Purdue University | Huntington | |
| Purdue University | Lafayette Jeff | |
| Purdue University | Rochester | |
| Purdue University | South Bend | |
| Purdue University | Syracuse | |
| Purdue University | Walton | |
| STATE | ||
| SITE | WINNER | CLASS |
| Old Coliseum, Indianapolis | Franklin | |